Work

Cavitary Lung Lesion as the Initial Presentation of Diffuse Large B-Cell Lymphoma: A Case Report With Review of the Literature

Year: 2026

Type: article

Abstract: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma and may rarely present with pulmonary involvement, creating significant diagnostic challenges. We report the case of a 69-year-old man who presented with a persistent cavitary right lower lobe lung lesion initially treated as recurrent pneumonia. Despite multiple courses of antimicrobial therapy, his symptoms persisted, and extensive infectious etiology evaluation was unrevealing. Bronchoscopic biopsy ultimately demonstrated aggressive DLBCL. Subsequent evaluation revealed small bowel involvement, establishing systemic DLBCL with secondary pulmonary involvement. This case highlights an uncommon presentation of DLBCL masquerading as refractory pulmonary infection. We also review the previously reported cases of cavitary pulmonary DLBCL. Persistent cavitary lung lesions that fail to respond to appropriate antimicrobial therapy should prompt consideration of malignant etiologies and early tissue diagnosis.

Source: Cureus

DOI: 10.7759/cureus.116499

Authors: Hannah Mckenney, Sidharth Mahajan, Ronald Lands

Institutions: University of Tennessee Health Science Center, University of Tennessee Medical Center

Language: English

Topic: Lymphoma Diagnosis and Treatment

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7213548126