Work

Morita-Baylis-Hillman Allyl-Aryl Sulfoxides for the Dual Functionalization of Indoles via Interrupted Pummerer Rearrangement: Unlocking its Anticancer Potential

Year: 2026

Type: preprint

Abstract: Employing Morita-Baylis-Hillman derived trisubstituted allyl aryl sulfoxides for a one-step dual vicinal functionalisation of indoles for the first time towards the synthesis of 3-aryl-thio-2-allyl indoles. The reaction proceeds via sulfoxide activation, nucleophilic attack of indole and a charge-accelerated [3,3]sigmatropic rearrangement. Selected compounds from the synthesized library showed significant anticancer activity against MDA-MB-7 cell lines with low toxicity towards normal MCF-10A cell line highlighting their potential as anticancer agents.

Source: ChemRxiv

DOI: 10.26434/chemrxiv.15009042/v1

Authors: Aishwarya Subramanian, Trinadh Ballanki, Siddireddi Kalyanram, Vaishnu Suresh Kumar, Mohit Garg, Diego Quezada, Jebiti Haribabu, Baby Viswambharan

Institutions: Central University of Tamil Nadu, Birla Institute of Technology and Science, Pilani, Universidad Autónoma de Chile, University of Atacama

Language: English

Topic: Sulfur-Based Synthesis Techniques

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Department of Science and Technology, Ministry of Science and Technology, India

OpenAlex ID: W7213559589

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