Work

Socio-clinical profiles and life satisfaction (LS) in individuals with emerging cognitive disorders (MCI or iSCCs) a multicenter cross-sectional study in French university-affiliated memory clinics

Year: 2026

Type: article

Abstract: Background: Mild cognitive impairment (MCI) and subjective cognitive complaints (SCCs) are risk factors for dementia, with significant human and economic impact. Life satisfaction (LS) remains underexplored across different cognitive profiles. Objectives: (1) To describe the socio-demographic and clinical characteristics of individuals according to MCI subtype (four groups based on amnestic/non-amnestic and single/multi-domain status) and isolated SCCs (iSCCs); (2) to compare LS between these groups; (3) to identify factors associated with low LS. Design and Methods: We conducted a cross-sectional analysis of 2,252 participants from the French Memento cohort, recruited in 26 university-affiliated memory clinics. LS was assessed through a standard single-item measure and dichotomised into high vs. low satisfaction. Logistic regression models examined associations with cognitive, clinical, functional, and psychosocial variables Results: LS did not differ significantly across cognitive subtypes, despite socio-demographic and clinical differences. In contrast, participants with a Clinical Dementia Rating (CDR) of 0.5 reported lower LS than those with a CDR of 0, highlighting an association between perceived LS and global clinical stage rather than subtype. Main factors associated with low LS included mood disorders, poor self-rated health, perceived lack of freedom, and weak social networks. Conclusion: In emerging cognitive disorders, LS is influenced more by modifiable psychosocial factors than by cognitive subtype. This highlights the need to strengthen person-centered interventions from earliest stages of cognitive decline - whatever form - with particular focus on mood, sense of autonomy and social connection. Memory clinics (alongside general practitioners) are key in identifying vulnerabilities and providing targeted multidisciplinary support.

Source: Journal of Public Health Research

DOI: 10.1177/22799036261487220

Author: Yaël Tibi-Levy

Institutions: Centre National de la Recherche Scientifique, Inserm, Université Paris Cité, Centre de Recherche Médecine, Sciences, Santé, Santé Mentale, Société, École des hautes études en sciences sociales

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,500