Work

Accompanying data for "EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse"

Year: 2026

Type: dataset

Abstract: Datasets and derived objects accompanying King et al., "EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse" (Nature Medicine, 2026; doi:10.1038/s41591-026-04665-3). Includes Salmon transcript quantifications for 130 CD19+ bulk RNA-seq samples, Cell Ranger filtered feature-barcode matrices for 28 scRNA-seq wells with Vireo donor assignments for the 23 multiplexed pools, 46 CD19+ flow cytometry FCS files, EBV RT-qPCR Ct values, NEBULA differential expression results, scDist fits, and the annotated Seurat objects. Analysis code is at https://github.com/TNRC-MGB/RRMS-Biomarkers. Raw sequencing data are in GEO (scRNA-seq: GSE347634; bulk RNA-seq: GSE344578). Whole-genome sequencing is controlled access. MD5SUMS.txt lists checksums for all files.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.22806569

Authors: King, Devin A., Saxena, Shrishti, Caefer, Danielle, Downer, Kyle C., Saucier, Laura E., Goodman, Ethan, Aracena, Jonmichael, Zhirova, Alena, Alchanat, Anthilia, Nolan, Saoirse, Lokhande, Hrishikesh, Weiner, Howard L., Gewurz, Benjamin E., Chitnis, Tanuja

Institutions: Brigham and Women's Hospital, Harvard University, Mass General Brigham, Broad Institute

Language: English

Topic: Multiple Sclerosis Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7213598822

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