Work

An expanded role for DNA Polymerase Theta in Single-Strand Annealing reveals a distinct repair signature in Homologous Recombination Deficient Cancers

Year: 2026

Type: software

Abstract: This repository deposits the code used in this paper: ssa_polq_2025.zip - Code used to determine homology and homeology attribution for deletions detected using AAVS1-seq. delmh_ssa.zip - Code used to identify and characterize single-nucleotide-variant (SNV) deletions associated with homeology in tumor samples. SV_DELETION_HOMEOLOGY.zip - Code used to identify and characterize structural variant (SV) deletions associated with homeology in tumor samples.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.22835311

Authors: Jalan, Manisha, Buechelmaier, Erika, Rafailov, Johnathan, Zhu, Yingjie, Pei, Xin, Brylka, Sebastian, Gomez-Aguilar, Joan, McDermott, Niamh, Riaz, Nadeem, Imieliński, Marcin, Powell, Simon

Institutions: Memorial Sloan Kettering Cancer Center, Mayo Clinic, Mayo Clinic in Florida, Weill Cornell Medicine, Mayo Clinic Comprehensive Cancer Center (Florida), New York Genome Center, NYU Langone’s Laura and Isaac Perlmutter Cancer Center, New York University

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7213630243

Cites:

Cited by:

Related to: 10