Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial
Year: 2026
Type: article
Abstract: In the coronavirus efficacy (COVE) phase 3 clinical trial, vaccine recipients were assessed for neutralizing and binding antibodies as correlates of risk for COVID-19 disease and as correlates of protection. These immune markers were measured at the time of second vaccination and 4 weeks later, with values reported in standardized World Health Organization international units. All markers were inversely associated with COVID-19 risk and directly associated with vaccine efficacy. Vaccine recipients with postvaccination 50% neutralization titers 10, 100, and 1000 had estimated vaccine efficacies of 78% (95% confidence interval, 54 to 89%), 91% (87 to 94%), and 96% (94 to 98%), respectively. These results help define immune marker correlates of protection and may guide approval decisions for messenger RNA (mRNA) COVID-19 vaccines and other COVID-19 vaccines.
Source: UNC Libraries
DOI: 10.17615/fc0d-ap41
Authors: United States Government (USG)/CoVPN Biostatistics Team, McDanal, Charlene, Eaton, Amanda, Corey, Lawrence, Lin, Bob C., Zhou, Honghong, Fong, Youyi, Immune Assays Team, Miller, Jacqueline, Kalams, Spyros, Pajon, Rolando, Donis, Ruben O., Jayashankar, Lakshmi, Kelley, Colleen F., Kublin, James G., Sarzotti-Kelsoe, Marcella, Montefiori, David C., van der Laan, Lars W. P., Moderna, Inc. Team, El Sahly, Hana M., Yu, Chenchen, Koup, Richard A., Flach, Britta, Deng, Weiping, Baden, Lindsey R., Lu, Yiwen, Hejazi, Nima S., Coronavirus Vaccine Prevention Network (CoVPN)/Coronavirus Efficacy (COVE) Team, Borate, Bhavesh, Gilbert, Peter B., Baron, Mira, O’Connell, Sarah, Houchens, Christopher R., Martins, Karen, Huynh, Chuong, Follmann, Dean, Castellino, Flora, Neuzil, Kathleen M., Benkeser, David, Andrasik, Michele P., McDermott, Adrian B., Carpp, Lindsay N., Gay, Cynthia, De La Cruz, Luis
Institution: University of North Carolina at Chapel Hill
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: U.S. Department of Health and Human Services, Bill and Melinda Gates Foundation, Wellcome Trust, National Institutes of Health, Centers for Disease Control and Prevention, U.S. Public Health Service, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences
OpenAlex ID: W7213650386
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