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Severe upper gastrointestinal hemorrhage in a renal transplant recipient: A potential complication of immunosuppressive therapy

Year: 2026

Type: article

Abstract: Upper gastrointestinal bleed (UGIB) is a significant and potentially life-threatening complication in renal transplant recipients, frequently associated with immunosuppressive therapy. We present a case of a 38-year-old male renal transplant recipient who experienced recurrent UGIB due to duodenal and gastric ulcers during the early postoperative period. His immunosuppressive regimen, initially consisting of antithymocyte globulin, steroids, tacrolimus, and mycophenolate mofetil (MMF), was adjusted multiple times in response to persistent bleeding episodes. Despite numerous endoscopic, radiological, and surgical interventions, his condition necessitated further immunosuppressive modulation, including cessation of MMF and introduction of belatacept, which ultimately stabilized his gastrointestinal condition. This case underscores the complexities of managing UGIB in renal transplant recipients under immunosuppressive therapy and highlights the need for a tailored multidisciplinary approach to optimize outcomes while preserving graft function.

Source: SAGE Open Medical Case Reports

DOI: 10.1177/2050313x261420025

Authors: Elhassan Mahmoud, Yousra Ali, Ibrahim M. Obeidat, Souraia Mezhoud, Rafie A. Yakoob

Institution: Hamad Medical Corporation

Language: English

Topic: Renal Transplantation Outcomes and Treatments

Subfield: Transplantation

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,000