Work

In Silico Design and Immunogenicity Studies of Two Multi-Epitope Vaccines against Klebsiella pneumoniae

Year: 2026

Type: article

Abstract: Highlights • 44 conserved B cell epitopes from 8 K. pneumoniae virulence factors were identified. • Two multi-epitope vaccine constructs were predicted to be highly antigenic. • Multi-epitope vaccine constructs were sequence optimized and predicted to be stable. • Constructs were predicted to be non-homologous, non-allergenic, and non-toxic human peptides. • Both multi-epitope vaccines were predicted to elicit humoral and cellular responses.

Source: Computational and Structural Biotechnology Journal

DOI: 10.34133/csbj.0232

Authors: Marta Vicente-Pazos, Mireia López-Siles, Michael J. McConnell

Institutions: Universidad Nacional de Educación a Distancia, Universitat de Girona, Instituto de Salud Carlos III, University of Notre Dame

Language: English

Topic: vaccines and immunoinformatics approaches

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,230