Work

Nasal epithelial transcriptome-wide isoform-level expression and asthma endotypes in youth

Year: 2026

Type: article

Abstract: BACKGROUND: Previous transcriptome-wide association studies of asthma lacked analyses of isoform expression. OBJECTIVE: We sought to identify isoforms associated with asthma endotypes in children and adolescents. METHODS: 17-low asthma as the reference group) in 459 youths with asthma aged 8-20 years in 3 studies: Epigenetic Variation and Childhood Asthma in Puerto Ricans (EVA-PR), Stress and Treatment Response in Puerto Rican and African American Children With Asthma (STAR), and Vitamin D Kids Asthma (VDKA). Genes or isoforms with the same direction of association with an endotype in all cohorts and a meta-analysis false discovery rate-adjusted P < .01 were considered to have significantly differential expression. RESULTS: 17-high asthma, 113 genes (encoding 160 isoforms) altered isoform usage, including SBNO2, PSMB8, and NCOA7. CONCLUSIONS: An isoform-level analysis complemented a gene-level analysis of expression and identified novel genes for asthma endotypes.

Source: Journal of Allergy and Clinical Immunology

DOI: 10.1016/j.jaci.2026.09.005