Work

Diastereoselective synthesis of substituted cyclopentanones via [3 + 2] cycloaddition of sulfoxonium ylides with alkenes

Year: 2026

Type: article

Abstract: -1,2-disubstituted alkenes support a stepwise cyclisation mechanism. The cyclopentanone products are versatile intermediates to other valuable compound classes such as diastereomerically pure δ-lactones and cyclopentanols.

Source: Chemical Science

DOI: 10.1039/d6sc05806j

Authors: Jihyeon Yeo, Sebastian M. Krajewski, Jonathan A. Ellman

Institution: Yale University

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: National Institutes of Health, National Institute of General Medical Sciences

Award: Next-generation C-H functionalization methods for organic synthesis and their applications to biological inquiry

OpenAlex ID: W7213878450

FWCI:

Cites: 61

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Related to: 10