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Redirecting Iodine Oxidation in Thyroxine by O-Phosphorylation

Year: 2026

Type: preprint

Abstract: [email protected] Abstract O-Phosphorylation of a thyroxine derivative redirects mCPBA oxidation from the internal iodine to a terminal one. A two-step oxidation-hydrolysis sequence delivers the phosphate-stabilised aryl(hydroxy)iodonium salt, whose regiochemistry is established by 3 J-CP-coupling.

Source: ChemRxiv

DOI: 10.26434/chemrxiv.15009163/v1

Authors: Marcel Sancken, Felix Schindler, Boris J. Nachtsheim

Institution: University of Bremen

Language: English

Topic: Oxidative Organic Chemistry Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

OpenAlex ID: W7213881684

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