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Cronkhite-Canada Syndrome Associated with Primary Cutaneous Peripheral T-cell Lymphoma and Membranous Nephropathy: A Case Report

Year: 2026

Type: article

Abstract: Cronkhite-Canada syndrome (CCS) is a rare disorder characterized by gastrointestinal polyposis and ectodermal abnormalities. We report the case of a 64-year-old man with CCS complicated by primary cutaneous peripheral T-cell lymphoma (PC-PTCL) and membranous nephropathy. Cutaneous lymphoma was controlled using topical corticosteroids and phototherapy. During the clinical course of CCS, the patient developed proteinuria, and a renal biopsy revealed membranous nephropathy with equivocal phospholipase A2 receptor staining. Corticosteroid therapy improved both the gastrointestinal manifestations and proteinuria. This case suggests a possible immune-mediated association among CCS, PC-PTCL, and membranous nephropathy.

Source: Internal Medicine

DOI: 10.2169/internalmedicine.7143-26

Authors: Kohei Kiso, Yusuke Shimoyama, Saki Okuda-Hiwatashi, Taku Fujimura, Yoshihide Asano, Rui Makino, Tetsuhiro Tanaka, Hideya Iwaki, Daisuke Okamoto, Hiroshi Nagai, Takeo Naito, Rintaro Moroi, Yoichi Kakuta, Atsushi Masamune

Institution: Tohoku University

Language: English

Topic: Genetic factors in colorectal cancer

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7213895156

FWCI:

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