Year: 2026
Type: article
Study design: Observational Study
Abstract: BACKGROUND AND OBJECTIVE: Cardiovascular disease (CVD) is a prevalent comorbidity in asthma, yet its impact on clinical outcomes across disease states remains poorly characterised. METHODS: We analysed data from two independent prospective cohorts. Cohort I comprised 1058 stable asthma patients (CVD: n = 107; non-CVD: n = 951) followed for 12 months to assess asthma exacerbations. Cohort II comprised 825 patients hospitalised for an acute exacerbation (CVD: n = 233; non-CVD: n = 592). Missing data were handled by multiple imputation, and the CVD and non-CVD groups were balanced using propensity score overlap weighting. Associations were estimated using negative binomial, gamma, and logistic regression. Mediation and dominance analyses were performed as exploratory analyses. RESULTS: /FVC ratio, while monocytes additionally mediated the association between CVD and severe exacerbations. In Cohort I, CVD was independently associated with severe exacerbations (adjusted IRR = 1.96, 95% CI (1.12, 3.44)), hospitalisations, and emergency visits. In Cohort II, CVD was associated with longer hospital stay (adjusted IRR = 1.14, 95% CI (1.01, 1.30)) and higher direct costs, with stroke and coronary heart disease as leading contributors to prolonged stay. CONCLUSION: CVD is independently associated with worse clinical outcomes across the asthma disease spectrum. These findings support recognition of CVD as an important treatable trait in asthma and highlight the need for integrated cardiopulmonary management.
Source: Respirology
DOI: 10.1002/resp.70317
Institutions: Sichuan University, West China Medical Center of Sichuan University, West China Hospital of Sichuan University, Tongji Hospital, Huazhong University of Science and Technology, Asan Medical Center, University of Ulsan, Central South University, Xiangya Hospital Central South University, King's College London, Shanghai Jiao Tong University, XinHua Hospital, Nagoya City University, Second Affiliated Hospital of Jilin University, John Hunter Hospital, Hunter Medical Research Institute, University of Newcastle Australia, Royal Brompton & Harefield NHS Foundation Trust, Harefield Hospital, Royal Brompton Hospital, Imperial College London
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W7213896335