Work

pSIM: A next generation in vitro mRNA potency assay

Year: 2026

Type: article

Abstract: neutralization in mice, and establish stability-indicating performance under heat stress, real-time storage, freeze-thaw, and RNA-lipid adduct formation. The assay is co-qualified for early phase quality control implementation to support phase-appropriate release and stability testing.

Source: Molecular Therapy Advances

DOI: 10.1016/j.omta.2026.201850

Authors: Marissa K. Fox, Zhijun Cao, Hima Sapa, Zhichun Wang, William R. Schutt, Raveen Rathnasinghe, Ying Zhang, Jiang Qian

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Seqirus

OpenAlex ID: W7213904157

FWCI:

Cites: 38

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Related to: 10