Year: 2026
Type: preprint
Abstract: The node–module logic underpins DNA, RNA, and metal–organic frameworks. In small-molecule synthesis, SuFEx and PFEx exploit sulfur or phosphorus as single‑atom nodes for 10 modular ligations but are largely confined to amine and phenol modules. Silicon‑based ligation would offer a viable alternative, as both alcohols and phenols can serve as reliable modules, yet it has lacked efficient and controllable platforms. Herein, we report a silicon-noded ligation platform using bis(2,4,6-trimethoxyphenyl)silanes (bis(TMP)silanes) as the ligation hubs, enabling rapid, high-yielding ligation of both alcohol and phenol modules with broad functional-group tolerance.
Source: ChemRxiv
Authors: Jie Wang, Zhiyou Hu, Youliang Wang
Institution: Xi'an Jiaotong University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
Award: G2663463710
OpenAlex ID: W7213950314