Year: 2026
Type: article
Abstract: Toxoplasmosis, caused by the parasite Toxoplasma gondii, has traditionally been associated with congenital infection and immunocompromised patients. Recent evidence suggests that latent infection may also contribute to the development of several mental disorders. This paper reviews the epidemiological literature on the association between T. gondii seropositivity and mental health outcomes, with a focus on schizophrenia, bipolar disorder, and suicidal behaviour. The analysis draws on published meta-analyses and systematic reviews. The findings indicate that the association is consistent across multiple studies and that the attributable disease burden is substantial. The paper concludes that T. gondii infection represents a neglected but potentially preventable risk factor for mental illness, and that a One Health approach integrating human, animal, and environmental health offers a practical framework for addressing this issue.
Source: Theoretical and Natural Science
Author: Hanjun Mao
Institution: King's College London
Language: English
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W7213970947