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Sustained Propranolol Use and Site-Specific All-Cause Mortality after Cancer Diagnosis: A Nationwide Taiwan Cohort Study

Year: 2026

Type: article

Abstract: In this nationwide East Asian cohort, sustained propranolol use was associated with lower all-cause mortality, most evident in genitourinary and digestive system cancers. These associations are hypothesis-generating rather than causal, given the observational design and unmeasured confounders including cancer stage and treatment, and support prioritising these categories for prospective evaluation of propranolol as a candidate for oncological repurposing. Because the exposure definition required survival to completion of a six-month treatment window, residual immortal time and selection bias cannot be excluded and the magnitude of the association may be overstated.

Source: Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics

DOI: 10.32604/or.2026.086291