Work

Activatable 19 F NMR probes from drug scaffolds for assessing myeloperoxidase-associated inflammation

Year: 2026

Type: article

Abstract: In this work, we constructed 14 nitrone-derived 19 F NMR probes for HClO detection, among which 19FP-10 proved capable of reliably quantifying HClO in septic mouse plasma and distinguishing inflamed from normal brain tissue.

Source: Chemical Science

DOI: 10.1039/d6sc06063c

Authors: Xiangjie Luo, Xinran Ji, Zhuoying Chen, Haoyu Wu, Han Cheng, Bing Zhang, Yong Qian

Institutions: Nanjing Normal University, Nanjing Drum Tower Hospital, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing University

Language: English

Topic: Molecular Sensors and Ion Detection

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Natural Science Foundation of China, Government of Jiangsu Province, Natural Science Foundation of Jiangsu Province, Nanjing University, State Key Laboratory of Pharmaceutical Biotechnology

Awards: G1431512418, G5496377171, G5883138372, G6503732114

OpenAlex ID: W7213983090

FWCI:

Cites: 50

Cited by:

Related to: 10