Causes of death across the life course in the Association of Southeast Asian Nations (ASEAN): a systematic analysis for the Global Burden of Disease Study 2023
Year: 2026
Type: article
Abstract: BACKGROUND: The drivers of mortality and their associated risk factors evolve throughout the course of life. Understanding these transitions is essential for effective, equitable, and age-appropriate health interventions. METHODS: As part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023, we examined life expectancy and the probability of death from birth to age 70 years (70q0) from 1990 to 2023 for each Association of Southeast Asian Nations (ASEAN) member state. In addition, we assessed causes of death and risk factor by age and sex across different life stages. Life expectancy was estimated from age-specific mortality rates with standard demographic techniques, and 70q0 from mortality and GBD life tables. Cause-specific mortality was estimated using the Cause of Death Ensemble model, and risk-attributable mortality using the comparative risk assessment framework. FINDINGS: In 2023, regional life expectancy was 70·1 years (95% uncertainty interval 69·6-70·7) for males and 76·2 years (75·7-76·7) for females, ranging from 87·5 years (87·3-87·8) for females in Singapore to 62·1 years (60·8-63·5) for males in Myanmar. Correspondingly, all-cause 70q0 was higher for males than for females. Neonatal disorders were the leading cause of mortality among infants younger than 1 year. Road injuries were the primary driver of mortality among males from adolescence through to early adulthood, accounting for 25·0% (17·0-31·0) of total mortality (8230 [5740-10 800] deaths) in males aged 15-19 years, with mortality rates varying from 3·0 per 100 000 population (2·3-3·7) to 49·0 per 100 000 population (25·0-67·1) between countries. Among females, maternal disorders were the leading cause of death in ages 25-34 years. In mid-adulthood, non-communicable diseases such as ischaemic heart disease and stroke emerged as major causes. Tobacco use was the dominant risk factor across most of adulthood in males, whereas high blood pressure was the prevailing risk factor among adult females. INTERPRETATION: Although the leading causes of death have converged across countries, the outcomes of these causes remain divergent, reflecting persistent inequalities across the region. These patterns present a strategic opportunity for multilateral action to mobilise collective resources and achieve regional health equity. FUNDING: Gates Foundation.
Source: The Lancet Public Health
Authors: Taishun Li, Periklis Charalampous, Stephanie C C van der Lubbe, Yawen Zhou, Simon I Hay, Jeofrey Bautista Abalos, Edimansyah Abdin, Hanif Abdul Rahman, Asnawi Abdullah, Abdulrakib Abdulrahim, Michael R M Abrigo, Wirawan Adikusuma, Tawseef Ahmad, Sima Ahmadpour, Mohamed Mustaf Ahmed, Budi Aji, Mohammed Alfaqeeh, Khaidar Ali, Syed Mohamed Aljunid, Joseph Uy Almazan, Ali Salman Al-Shami, Junaid Amin, Roshan A Ananda, Chin-Siang Ang, Nguyen Hoang Anh, Sumadi Lukman Anwar, Irfan Ardani, Rizal Arifin, Keivan Armani, Mohammad Ashfaq, Muhammad Shahzad Aslam, Yuni Asri, Zaw Zaw Aung, Zulfa Ayuningsih, Fitriyono Ayustaningwarno, Abul Kalam Azad, Mohd Yusmaidie Aziz, Ahmed Bali, Muhammad Irfan Bashir, Bagas Suryo Bintoro, Ahmad Naoras Bitar, Ai Cao My Bui, Asmat Burhan, Muhammad Daoud Butt, Dimples Acquiatan Camporedondo, Yu Cao, Hana Chen, Nicholas WS Chew, Ruixin Chi, Bryan Chong, Dennis Chong, Karleen Chong, Christina Malini Christopher, Dinh-Toi Chu, Mayank Dalakoti, Pojsakorn Danpanichkul, Bryan Gervais de Liyis, Edward Christopher Dee, Sadia Din, Mai Ngoc Do, Thao Huynh Phuong Do, Minh Cuong Duong, Angel Belle Cheng Dy, Ferry Efendi, Ekawati Ekawati, Muhammad Esa, Maryam Farooqui, Nelsensius Klau Fauk, Neeraj Kumar Fuloria, Shivkanya Fuloria, Francis Sarial Ganancial, Fernando Jr Barroga Garcia, Adrian Eleazar Go, Bey Hing Goh, Ernesto Ramos Gregorio, Nguyen Hai Nam, Harapan Harapan, Arief Hargono, Andy Martahan Andreas Hariandja, Faizul Hasan, Zaw Myo Hein, Rohman Hikmat, Aaron Kwun Hang Ho, Tinh Ho Huu, Mehdi Hosseinzadeh, Mega Hasanul Huda, Fadly Husain, Mohd Salami Ibrahim, Umar Idris Ibrahim, Korakrit Imwattana, Lalu Muhammad Irham, Fahrul Islam, Jazlan Jamaluddin, Roland Dominic G Jamora, Hanish Singh Jayasingh Chellammal, Yovanthi Anurangi Jayasinghe, Jost B Jonas, Muhammad Khan, Parisa Khoshvaght, Siti Khuzaiyah, Ko Ko, Soewarta Kosen, Chong-Han Kua, Garry Kuan, Yee Cheng Kueh, Maria Dyah Kurniasari, Dea Anita Ariani Kurniasih, Asep Kusnali, Aria Kusuma, Dian Kusuma, Daphne Teck Ching Lai, Agung Dwi Laksono, Tri Laksono, Jerrald Lau, Bao Huy Le, Thao Thi Thu Le, Hoi Leong Lee, Shaun Wen Huey Lee, Elvynna Leong, Mohammad Farris Iman Leong Bin Abdullah, Retno Lestari, Mei Fong Liew, Lee-Ling Lim, Donglin Liu, Xiao Liu, Arianna Maever Loreche, Hung N Luu, Kaung Suu Lwin, Zheng Feei Ma, Melani Ratih Mahanani, Roy Rillera Marzo, Richard James Maude, Muhammad Miftahussurur, Muhammad Agus Mikrajab, Long Chiau Ming, Maziar Moradi-Lakeh, Amartya Mukhopadhyay, Lutfi Muzaqi, Kiran P Nagdeo, Firzan Nainu, Tam Thi Ngo, Cao Duy Nguyen, Ha Thu Nguyen, Hien Thu Nguyen, Hien Thi Nguyen, Long Hoang Nguyen, Minh Thien Nguyen, Minh-Ha Nguyen, Nghia Phu Nguyen, Thanh Van Nguyen, Thinh Gia Nguyen, Luong Nguyen Thanh, Cham Thi Nguyen Thi, Ricvan Dana Nindrea, Mohammed Noushad, Nurfatimah Nurfatimah, Ahmad Dzulfikri Nurhan, Sok King Ong, Sandersan Onie, Zhinya Kawa Othman, Helena Ullyartha Pangaribuan, Santa Maria Pangaribuan, Bunga A Paramashanti, Veincent Christian Filipino Pepito, Tung Thanh Pham, Dimitri Poddighe, Kian Keong Poh, Thantrira Porntaveetus, Ragil Angga Prastiya, Yusuf Alif Pratama, Hery Purnobasuki, Nuzul Qur'aniati, Ali Qureshi, Basuki Rachmat, Asad Ur Rahman, Vignesh Ramachandran, Kadar Ramadhan, Sheena Ramazanu, Ateeq Rehman, Yohanes Andy Rias, Erna Rochmawati, Alina Rodriguez, Iftitakhur Rohmah, Thanakorn Rojanathagoon, Chanapong Rojanaworarit, Debby Syahru Romadlon, Betty Roosihermiatie, Bedanta Roy, Suebsarn Ruksakulpiwat, Ahmad Sahban Rafsanjani, Shuaibu Musa Saidu, Yoseph Leonardo Samodra, Lintang Dian Saraswati, Shilpa Sarawagi, Ni Putu Wulan Purnama Sari, Mohammad-Ali Sarvghadi, Tual Sawn Khai, Abrar Mohammad Sayaf, KT Matthew Seah, Zhi Huang See, Siddharthan Selvaraj, Shazlin Shaharudin, JiaHao Shi, Ching-Hui Sia, Robert Sinto, Chandrashekhar T Sreeramareddy, Vetriselvan Subramaniyan, Chee Fai Sui, Desy Sulistiyorini, Henry Surendra, Suryanti Suryanti, Herry Susanto, Hani Susianti, Tri Nugraha Susilawati, Dayinta Annisa Syaiful, Balamurugan Tagiisuran, Ching Siang Tan, Kit-Aun Tan, Ekamol Tantisattamo, Ingan Ukur Tarigan, Andrew W Taylor-Robinson, Van Chi Thai, Lakshmi Thangavelu, Hein Thu, Jansje Henny Vera Ticoalu, Santo Imanuel Tonapa, Nam Minh-phuong Tran, Nam Hoang Tran, Quynh Thuy Huong Tran, Thang Huu Tran, Thi Thuy Vy Tran, Nguyen Tran Minh Duc, Indang Trihandini, Quynh Xuan Nguyen Truong, Abdul Rohim Tualeka, Sok Cin Tye, Josefien van Olmen, Narayanaswamy Venketasubramanian, Nguyen-Kieu Viet-Nhi, Tuan Vinh, Lan Thi Hoang Vu, Linh Vu, Thinh Toan Vu, Ali Wagdy, Mugi Wahidin, Tati Suryati Warouw, Apichai Wattanapisit, Taweewat Wiangkham, Yohanes Cakrapradipta Wibowo, Akhmad Fajri Widodo, Angga Wilandika, Sri Winarni, Utoomporn Wongsin, Mun Fei Yam, Kwang Mo Yang, Siyan Yi, Mustafa Younis, Riky Tri Yunardi, Emilia Zainal Abidin, Lilik Zuhriyah, Mohsen Naghavi, Marie Ng, Cuilin Zhang
Institutions: National University of Singapore, Nanjing Drum Tower Hospital, Nanjing University, Erasmus MC, University of Washington, Institute for Health Metrics and Evaluation, University of Eastern Pangasinan, Institute of Mental Health, Universiti Brunei Darussalam, Universitas Muhammadiyah Aceh, Kementerian Kesehatan Republik Indonesia, Universiti Putra Malaysia, National Research and Innovation Agency, Prince of Songkla University, COMSATS University Islamabad, Universiti Tunku Abdul Rahman, SIMAD University, Jenderal Soedirman University, Padjadjaran University, IMU University, National University of Malaysia, Nazarbayev University, Sana'a University, Universiti Malaysia Sarawak, Universiti Sains Malaysia, University of Ha'il, Eastern Health, Imperial College London, Nanyang Technological University, Thai Binh University of Medicine and Pharmacy, Universitas Gadjah Mada, Muhammadiyah University of Ponorogo, UCSI University, Chulalongkorn University, Woxsen School of Business, Xiamen University Malaysia, Institut Teknologi, Sains, dan Kesehatan RS.DR. Soepraoen Kesdam V/BRW, Walisongo State Islamic University, Diponegoro University, Universiti Antarabangsa MAIWP, Duy Tan University, Jadara University, Sultan Zainal Abidin University, University of Medicine and Pharmacy at Ho Chi Minh City, Universitas Harapan Bangsa, Caraga State University, Curtin University, University of Cyberjaya, University of Cambridge, University of Malaya, Vietnam National University, Hanoi, VNU International School, Texas Tech University, National Brain Centre, Memorial Sloan Kettering Cancer Center, Gachon University, Can Tho University of Medicine and Pharmacy, UNSW Sydney, Ateneo de Manila University, London School of Hygiene & Tropical Medicine, La Trobe University, Universitas Airlangga, Torrens University Australia, AIMST University, China Medical University, University of the Philippines Manila, Cebu Institute of Medicine, University of Technology Sydney, Sunway University, Thong Nhat Hospital, Universitas Syiah Kuala, Ajman University, National University Hospital, Western Caspian University, University of Indonesia, State University of Semarang, Baylor College of Medicine, Mahidol University, Universitas Ahmad Dahlan, Poltekkes Kemenkes Mamuju, St. Luke's Medical Center, Universiti Teknologi MARA System, Universiti Teknologi MARA, Cephas Health Research Initiative, Hôpital Rothschild, Singapore Eye Research Institute, Riphah International University, Universitas Muhammadiyah Pekajangan Pekalongan, Hiroshima University, Republic Polytechnic, Henan University, Satya Wacana Christian University, Taipei Medical University, Khalifa University of Science and Technology, Institute of Applied Data Analytics, Universitas 'Aisyiyah Yogyakarta, Pham Ngoc Thach University of Medicine, Universiti Malaysia Perlis, Monash University Malaysia, Taylor's University, Henan Medical University, University of Brawijaya, Alexandra Hospital, Chinese University of Hong Kong, Chiang Mai University, Duke-NUS Medical School, Houston Methodist, Houston Methodist Research Institute, University of Huddersfield, University of the West of England, Heidelberg University, Heidelberg Institute of Global Health, Curtin University Sarawak, University of Oxford, Mahidol Oxford Tropical Medicine Research Unit, Universiti Malaysia Terengganu, Iran University of Medical Sciences, Tehran University of Medical Sciences, National University Health System, New York University, Hasanuddin University, Ton Duc Thang University, Hanoi School Of Public Health, Vanderbilt University, Methodist Hospital, Nam Can Tho University, The University of Sydney, Children's Hospital at Westmead, International University of Health and Welfare, Stockholm Resilience Centre, Stockholm University, VinUniversity, Universitas Negeri Padang, Poltekkes Kemenkes Palu, Ministry of Health, Harvard University, Krida Wacana Christian University, National University Heart Centre Singapore, National Heart Centre Singapore, Ramathibodi Chakri Naruebodindra Hospital, University of Kuala Lumpur, Hong Kong Metropolitan University, Saveetha University, Institut Ilmu Kesehatan Bhakti Wiyata, Muhammadiyah University of Yogyakarta, Anglia Ruskin University, University of Bristol, Hofstra University, Quest International University Perak, National Taiwan University, National Dental Centre of Singapore, Universitas Katolik Widya Mandala Surabaya, Hong Kong Polytechnic University, University of Warwick, University of Puthisastra, National Institute of Education, Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo, Universitas Indonesia Maju, Oxford University Clinical Research Unit Indonesia, Monash University, Universitas Dian Nuswantoro, Sultan Agung Islamic University, RSUD Prof. Dr. Saiful Anwar Malang, Sebelas Maret University, Joslin Diabetes Center, KPJ Healthcare University, American Heart Association, University of California, Irvine, University of Pennsylvania, The University of Western Australia, Sam Ratulangi University, Kaohsiung Medical University, Vietnam National University Ho Chi Minh City, Tokushima University, Kansai Medical University, University of Massachusetts Dartmouth, University of Antwerp, VNU University of Medicine and Pharmacy, York College, City University of New York, Naresuan University, Universitas 'Aisyiyah Bandung, Asia Pacific University of Technology & Innovation, Jackson State University
Language: English
Subfield: Demography
Field: Social Sciences
Domain: Social Sciences
Open Access status: gold
Estimated APC paid: $6,680
Funders: Bill and Melinda Gates Foundation, Vanderbilt University, UNICEF, Memorial Sloan-Kettering Cancer Center, Texas Tech University, Harvard University, University of Washington, Joslin Diabetes Center, Universiti Brunei Darussalam, COMSATS Institute of Information Technology, Iran University of Medical Sciences, Institute for Health Metrics and Evaluation, Asian Institute of Medicine, Science and Technology, Universitas Negeri Padang, Badan Riset dan Inovasi Nasional, York University, La Trobe University, National University of Singapore, University of New South Wales, University of Sydney, University of Technology Sydney, Curtin University of Technology, Gachon University, Mahidol University, Prince of Songkla University, Universiti Kebangsaan Malaysia, Universiti Putra Malaysia, Universiti Sains Malaysia, Ateneo de Manila University, China Medical University, University of the Philippines, Nanjing University, Universiti Malaysia Sarawak, Universitas Airlangga, University of Hail, Stockholms Universitet, International Medical University, Universiti Kuala Lumpur, Universitas Hasanuddin, National University Health System, Universiti Malaysia Terengganu, Nazarbayev University, Jenderal Soedirman University, Universitas Padjadjaran, Ministry of Health of the Republic of Indonesia, Universitas Muhammadiyah Aceh, Nanjing Drum Tower Hospital, National Institutes of Health, Đại học Quốc gia Hà Nội, Erasmus Universitair Medisch Centrum Rotterdam, Sunway University, Institute of Tropical Aquaculture and Fisheries, University Malaysia Terengganu
OpenAlex ID: W7213995617