Iron-Catalyzed Defluorinative Alkylation for Accessing Cyclic Acetal– gem -Difluoroalkenes
Year: 2026
Type: article
Abstract: Cyclic acetals and gem-difluoroalkenes are proven structural motifs in medicinal chemistry, yet their modular incorporation into a densely functionalized hybrid architecture remains an uncharted frontier. Herein, we disclose an Fe-catalyzed reductive defluorinative cross-coupling between trifluoromethyl alkenes and 1,3-dioxolanyl- or 1,3-dioxepanyl-substituted alkyl iodides, enabling the rapid assembly of five- or seven-membered cyclic acetal-embodied fluorinated scaffolds, respectively. This protocol enriches defluorinative coupling versatility and offers streamlined access to structurally diverse pharmaceutically relevant scaffolds.
Source: Organic Letters
Institution: Chinese University of Hong Kong
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Awards: G3270949224, G3557125927, G4414803441, Exploration of Highly Tunable Phosphine Ligands Featuring Adaptive-Steric-Hindrance for Tackling Exceedingly Steric-Congested Cross-Coupling Reactions: Fundamental Investigations of Reaction Mechanisms and Fleeting Steric-On-Demand Interactions, Process Research and Industrialization of Potassium Bis(fluorosulfonyl)imide, an Intermediate for the Production of a New Lithium Salt for Lithium Battery, Process Research and Industrialization of Potassium Bis(fluorosulfonyl)imide, an Intermediate for the Production of a New Lithium Salt for Lithium Battery, G9000370164, G9000370277
OpenAlex ID: W7213999211