Work

Endoscopic multispectral imaging sensor systems for intraoperative tissue differentiation

Year: 2026

Type: article

Abstract: Significance: To remove the entire tumor area in cancer surgery, the margins are currently assessed by frozen sectioning or by analyzing the resected tissue afterwards. By utilizing spectral differences between healthy and malignant tissue, multispectral imaging (MSI) enables real-time tissue differentiation. Through miniaturization, the system can be used intraoperatively, thereby enabling the surgeon to define tumor margins, which reduces the need for a follow-up surgery. Aim: By obtaining characteristic spectral differences of healthy and malignant breast tissue, a miniaturized multispectral sensor system should be developed. The system should be compatible to commercial endoscopes, so that it can be used in minimally invasive endoscopic procedures. Approach: breast cancer study in the visible to shortwave infrared spectral range (450 to 1390 nm) and defined characteristic spectral differences. With these, we designed two MSI sensor systems, which only use few spectral channels, gaining a potentially real-time-capable sensor system. By miniaturization, they can be used intraoperatively with a commercial endoscope. Results: The final setups can be used with a commercial endoscope and allow for 90 deg field of view and a high spatial resolution, but showed limitations in the SWIR transmission. Conclusion: The two demonstrated systems are promising steps towards real-time endoscopic tissue differentiation.

Source: Journal of Biomedical Optics

DOI: 10.1117/1.jbo.31.9.097003

Authors: Kira Holstein, Alissa Tarnoruzki, Tobias Haist, Stephan Reichelt

Institution: University of Stuttgart

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,675