Work

Decoding enzyme-substrate interaction topology reveals principles underlying catalytic efficiency and mutational outcomes

Year: 2026

Type: preprint

Abstract: An Interpretable Bidirectional Cross-Attention Framework for Enzyme Catalytic Efficiency Prediction

Source: arXiv (Cornell University)

DOI: 10.24433/co.5279530.v1

Authors: Zhao, Weiren, Tamura, Takeyuki

Institutions: Kyoto University, Kyoto University Institute for Chemical Research

Language: English

Topic: Machine Learning in Bioinformatics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: Japan Society for the Promotion of Science

Awards: Development of metabolic control methods through the integration of machine learning and physics-based model optimization, G768380470

OpenAlex ID: W7164752294

Cites: 4

Cited by:

Related to: 10