Work

Cold plasma technology as a novel antimicrobial platform: mechanisms, efficacy, and clinical translation: a systematic literature review

Year: 2026

Type: review

Abstract: Background: The global antimicrobial resistance (AMR) crisis necessitates innovative therapeutic approaches beyond traditional antibiotics. Cold atmospheric plasma (CAP), an ionized gas containing reactive species, has emerged as a potent physical antimicrobial technology with broad-spectrum activity. This systematic review critically evaluates current evidence on CAP's antimicrobial mechanisms, efficacy against diverse pathogens, and clinical translation potential. Methods: , or clinically. Results: Analysis of 64 included studies revealed that CAP's antimicrobial effects primarily stem from reactive oxygen and nitrogen species generation, causing oxidative damage to microbial membranes, proteins, and DNA. CAP demonstrates significant efficacy against multi-drug-resistant bacteria, viruses, fungi, and biofilms. Clinical studies show particular promise in chronic wound management, with randomized controlled trials demonstrating accelerated healing and reduced microbial load. Conclusion: CAP represents a promising multi-target approach to antimicrobial therapy, offering a multi-target mechanism that circumvents conventional resistance pathways. While standardization and dosimetry challenges remain, CAP holds immense potential for integration into clinical practice against AMR.

Source: Infection Prevention in Practice

DOI: 10.1016/j.infpip.2026.100598

Authors: Amir Namvar Vansofla, Mohammad Ebrahim Minaei, Neda Yousefi Nojookambari, Sajjad Yazdansetad

Institutions: Imam Hossein University, Shahid Beheshti University, Shahid Beheshti University of Medical Sciences

Language: English

Topic: Atmospheric-Pressure Plasma Applications

Subfield: Atomic and Molecular Physics, and Optics

Field: Physics and Astronomy

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,500