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Immune determinants of cellular and humoral non-responsiveness to mRNA/LNP vaccination in immunocompromised individuals

Year: 2026
Type: preprint
Study design: Observational Study
DOI: 10.21203/rs.3.rs-10763567/v1
Authors: Nicholas M. Provine, Sam Murray, Jordan Rolt, Georgina Meacham, Vishal Rao, Stavros Dimitriadis, Kyla Dooley, Amelia Heslington, Carl Goodyear, Stefan Siebert, Iain McInnes, Michelle Willicombe, Maria Prendecki, David Thomas, Thushan de Silva, Adrian Shields, Alex Richter, Lucinda Billingham, Amanda Kirkham, Pamela Kearns, Barbara Kronsteiner, Paul Klenerman, susanna dunachie, Eleanor Barnes
Institutions: University of Oxford, Oxford University Hospitals NHS Trust, Newcastle University, University of Glasgow, Imperial College London, University of Cambridge, University of Sheffield, University of Birmingham, Cancer Research UK Clinical Trials Unit
Language: English
Field: Medicine
Open Access status: green
Funders: Government of the United Kingdom, UK Research and Innovation, Cancer Research UK, National Institute for Health and Care Research, Department of Health and Social Care, University of Oxford, UK Coronavirus Immunology Consortium, National Institutes of Health, Medical Research Council, NIHR Oxford Biomedical Research Centre
Awards: G1098815434, DTP Bid Led by University of Oxford, G2306515209, G3527110475, G4202993990, Optimising Vaccine Efficacy in Multi-Disease Patient Cohorts with SARS-CoV-2 vaccine failure (OCTAVE-DUO), G4525123623, G5267706263, G5331953782, G5514976981, G563290157, G564868737, G5918494183, G6928973985, G7289447374, Neutrophil heterogeneity in anti-neutrophil cytoplasm antibody associated vasculitis, G8415457339, (ICF)- IMMPROVE: Immune Memory and Mechanisms of Protection from Vaccines, Developing a vaccine to prevent death from melioidosis in people with type 2 diabetes mellitus in low- and middle-income countries, G8961154875
OpenAlex ID: W7214055778
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