Work

Structure-Based Optimization of 2-Aminopyrimidine Derivatives as Potent Multi-target FLT3/CHK1/IRAK4 Inhibitors for Acute Myeloid Leukemia

Year: 2026

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.6c01936

Authors: Xuemei Li, Kailong Jiang, Luyao Zhang, Xinyan Lan, Xiaozhen Chen, Ran Xu, Yue Gao, Peipei Wang, Xiaobei Hu, Yubo Zhou, Jia Li, Tao Liu

Institutions: Chinese Academy of Sciences, Zhejiang University, University of Chinese Academy of Sciences

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Natural Science Foundation of China, Basic and Applied Basic Research Foundation of Guangdong Province

Awards: G1835434903, G6629715141, G7214445029

OpenAlex ID: W7214068813

FWCI:

Cites: 32

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