Work

Stereoselective Polyglucuronic Acid Assembly via the Iron-Catalyzed Stereospecific Glycosylation with Glycal Epoxides

Year: 2026

Type: article

Abstract: Polyglucuronic acids (PGAs) are directly involved in essential biological processes, but catalytic methods for stereoselective PGA synthesis are underdeveloped because glucuronic acid (GlcA) donors are intrinsically difficult to activate. We report herein a convergent and stereoselective PGA assembly method via iron-catalyzed iterative and stereospecific glycosylation with glycal epoxides. This method is effective in the assembly of an array of GlcA-β-1,4-GlcA linkages in complex glycans and readily provides PGA octasaccharides in high stereoselectivity.

Source: Organic Letters

DOI: 10.1021/acs.orglett.6c03166

Authors: Xiao-Wen Zhang, Zixiang Jiang, Hao Xu

Institution: Brandeis University

Language: English

Topic: Carbohydrate Chemistry and Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Brandeis University, National Institutes of Health, National Institute of General Medical Sciences