Work

B cells enter the synaptic conversation

Year: 2026

Type: article

Abstract: Synapse loss is a defining feature of neurodegenerative disease, yet the signals that orchestrate synaptic elimination remain incompletely understood. Crowley and colleagues uncover an unexpected link between neuronal hyperactivity and adaptive immunity, showing that antibody-secreting B cells and immunoglobulins can drive complement-dependent synapse loss.

Source: Trends in Pharmacological Sciences

DOI: 10.1016/j.tips.2026.09.004

Authors: Terry R. Suk, David Gate

Institution: Northwestern University

Language: English

Topic: Neuroinflammation and Neurodegeneration Mechanisms

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $7,030