Work

Brain energy metabolism in neurodegenerative disease

Year: 2026

Type: review

Abstract: The brain is a highly complex organ composed of diverse, specialized cell types whose coordinated functions underpin cognition and behavior. While extensive research has elucidated neuronal signaling mechanisms, the metabolic interactions between distinct brain cells that sustain energy homeostasis are not yet comprehensively understood. Recently, brain energy metabolism has gained significant attention as a unifying factor in the pathogenesis of neurodegenerative diseases such as Alzheimer's and Parkinson's, potentially opening new avenues for therapeutic development. In this review, we provide an overview of brain energy metabolism, examine its role in neurodegeneration, and highlight current challenges and future perspectives in the field.

Source: Neurobiology of Disease

DOI: 10.1016/j.nbd.2026.107615

Authors: Carmen Maria Lahr, Elle Wilson, Melanie Sengupta, Michela Bernini, Alexander Skupin

Institutions: University of Luxembourg, Luxembourg Centre for Systems Biomedicine, University of California San Diego

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,180