Year: 2026
Type: article
Abstract: Metastatic tumors evade not only adaptive but also innate immune control. In a recent paper published in China Science Life Sciences , Jin and colleagues identify EID1 as a transcriptional and functional brake shared by dendritic cells (DCs) and natural killer (NK) cells. Genetic or nanoparticle-mediated EID1 inhibition strengthens DC-NK apposition, augments FPR1-dependent type I and II interferon responses through a mechanism involving FPR1 and potentially NK cell-derived ANXA1, and suppresses experimental metastatic colonization/outgrowth. The work connects a transcriptional-corepressor to innate immunosurveillance and suggests that the previously described ANXA1-FPR1 danger-sensing module may operate not only between dying cancer cells and DCs in primary sites, but also among NK cells and DCs at metastatic lesions.
Source: Immunity & Inflammation
Authors: Oliver Kepp, Guido Kroemer
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Funders: Seerave Foundation, Equipex, European Commission, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, Ligue Contre le Cancer, Institut National Du Cancer, Direction Générale de l’offre de Soins, Ministère des Solidarités et de la Santé, European Research Council, Horizon 2020
Awards: G1348591106, G1397743473, G1540355574, G1743485262, G1846858737, G1941370527, G2109069054, G2161503289, G2179318311, Lung cancer prevention and interception, Biomarkers affecting the transition from cardiovascular disease to lung cancer: towards stratified interception., G2351262490, G2469459663, Gut OncoMicrobiome Signatures (GOMS) associated with cancer incidence, prognosis and prediction of treatment response., G2699422577, G2714391379, Mitochondrial copper targeting to modulate inflammatory macrophages, G3489513111, G3745988485, G3772543176, G420978141, G4364925233, G4744413284, G4880911435, G4900465205, G4968846622, G4990482369, G540687550, Microbiota-centered interventions to solve antibiotics-induced primary resistance to immune checkpoint inhibitors, G5468290041, G5620085230, Energizing the failing heart, G5790172013, G5953624409, G6300988664, G6610179393, G6718544961, G69196502, G7080048889, G7309355080, G7319818416, G7662726268, G8316913482, G8386792218, The RUSH (retention using selective hooks) system: a chemical-genetic system for the in vivo manipulation of intercellular communication, G8991455713, G9000380285
OpenAlex ID: W7214113699