Year: 2026
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: Black women experience poor survival from epithelial ovarian cancer (EOC) for all stages at diagnosis and histotypes. The contribution of an ancestry-related genotype in the Atypical Chemokine Receptor 1 (ACKR1) gene to mortality after an EOC diagnosis in Black women has not been previously reported. METHODS: The relationship between the Duffy-null genotype (CC) in the ACKR1 gene and overall post-enrollment mortality in 408 Black women with EOC, including 275 with high-grade serous ovarian cancer (HGSC) was evaluated using Bayesian modeling approach to estimate hazard ratios (HR) and 95% credible intervals (CI) adjusting for stage, age at diagnosis, socioeconomic factors, and ovarian cancer family history. Tumor immune and genetic features were generated from sequencing assays on subsets of the HGSC cases. RESULTS: The CC genotype was associated with reduced all-cause mortality among EOC cases (adjusted HR = 0.60, 95% CI: 0.36-0.99). Among HGSC, the CC genotype was associated with higher African origin, lower ACKR1 expression (p = 0.049), lower cytotoxic T cell abundance (p = 0.062), and a higher frequency of homologous recombination deficient (HRD) tumors (p = 0.051). CONCLUSIONS: In this study, the Duffy-null CC genotype was associated with 40% lower EOC all-cause mortality in Black women. These are hypothesis-generating findings that require replication and further inquiry into mechanisms.
Source: Gynecologic Oncology
Authors: Joellen M. Schildkraut, Jeffrey R. Marks, Lauren C. Peres, Xintian Song, Anthony J. Alberg, Katherine A. Lawson-Michod, Courtney E. Johnson, Lindsay J. Collin, Jennifer A. Doherty, Elisa V. Bandera, Melissa L. Bondy, Theresa A. Hastert, Michele L. Coté, Edward S. Peters, Kristin Haller, Paul D. Terry, Michael P. Epstein, Yao Xin, Andrew B. Lawson
Institutions: Emory University, Duke University, Duke Medical Center, Moffitt Cancer Center, University of South Carolina, University of Washington, Fred Hutch Cancer Center, University of Utah, Huntsman Cancer Institute, Rutgers Cancer Institute, Stanford University, Wayne State University, The Barbara Ann Karmanos Cancer Institute, Indiana University Indianapolis, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, University of Nebraska Medical Center, University of Tennessee Medical Center, Medical University of South Carolina, University of Edinburgh
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,380
OpenAlex ID: W7214118326