Year: 2026
Type: article
Study design: Case Report
Abstract: Fungal keratitis is a potentially vision-threatening infection that can be difficult to treat when it involves the deep corneal layers.We report the case of a 50-year-old woman who developed deep central fungal keratitis following vegetative ocular trauma.Microbiological analysis identified Aspergillus flavus (A.flavus).Despite intensive topical treatment with voriconazole 1% and amphotericin B 0.15%, the infiltrate progressed after one week.A single intrastromal injection of voriconazole (50 µg/0.1 mL) was administered circumferentially around the infiltrate.Progressive clinical improvement followed, with complete resolution within one month and no recurrence during two years of follow-up.Final visual acuity was 20/100, with residual corneal scarring.This case highlights the potential role of intrastromal voriconazole as a targeted treatment option for deep, refractory fungal keratitis.
Source: Cureus
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7214150698