Work

Crosstalk between ubiquitination and other post-translational modifications in cardiovascular diseases

Year: 2026

Type: review

Abstract: Cardiovascular diseases (CVDs) remain a major cause of morbidity and mortality worldwide. Post-translational modifications (PTMs) are increasingly recognized as important regulators of cardiovascular pathophysiology, but how different PTMs interact in CVDs is still incompletely understood. This review focuses on the crosstalk between ubiquitination and other PTMs, including phosphorylation, SUMOylation, acetylation, methylation, O-GlcNAcylation, neddylation, and ADP-ribosylation/PARylation. We summarize representative cardiovascular mechanisms in which these modifications act competitively, cooperatively, or sequentially to influence protein stability, signaling, and function. We also discuss current limitations in establishing PTM interactions and highlight areas that require further investigation. A clearer understanding of these regulatory relationships may help identify disease-relevant PTM pathways and potential therapeutic targets in CVDs.

Source: iScience

DOI: 10.1016/j.isci.2026.117606

Authors: Yi Yan, Zhiqiang Li, Tingting Xiao

Institutions: Zhongda Hospital Southeast University, Jiangsu Province Hospital, Southeast University

Language: English

Topic: Ubiquitin and proteasome pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240