Thyrotoxic Periodic Paralysis as an Initial Manifestation of Hyperthyroidism in a Young Male Patient
Year: 2026
Type: article
Study design: Case Report
Abstract: Thyrotoxic periodic paralysis (TPP) is a rare but potentially fatal complication of hyperthyroidism, characterized by acute muscle weakness and hypokalemia. Although most frequently described in Asian populations, it can occur in other ethnic groups and is often underdiagnosed. We present the case of a 21-year-old Mexican man with acute lower-extremity weakness. Initial laboratory evaluation revealed a serum potassium level of 2.7 mEq/L and biochemical thyrotoxicosis. The patient received 60 mEq of intravenous potassium chloride over six hours, with complete recovery of muscle strength approximately eight hours after treatment initiation, supporting the diagnosis of TPP. Thyroid scintigraphy was suggestive of diffuse toxic goiter, while the elevated thyrotropin receptor antibody (TRAb) level supported Graves' disease as the underlying etiology. This case highlights the importance of considering TPP in the differential diagnosis of acute flaccid paralysis and emphasizes the need for early diagnosis and treatment to prevent potentially serious complications.
Source: Cureus
Author: Casandra Valadez Villalobos
Institution: Universidad Nacional Autónoma de México
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7214190199