Work

Gastric lipase and PLRP2 trigger the activity of pancreatic lipase on various emulsions stabilized by phospholipids or galactolipids

Year: 2026

Type: article

Abstract: . These findings show that the PL activity is not intrinsically limited by polar lipids at the interface, but dynamically regulated by prior interfacial conditioning. A mechanistic basis for the synergistic and sequential action of lipases is proposed, involving either a direct action of GL on TAG through its penetration of the interfacial layer or the digestion of DGDG or PC by PLRP2, both resulting in the production of FFAs facilitating PL-colipase adsorption. Early lipolysis events thus emerge as key determinants of lipid digestion.

Source: Food & Function

DOI: 10.1039/d6fo03954e

Authors: Carolina Quezada, Elizabeth Troncoso, Hélène Launay, Frédéric Carrière

Institutions: Metropolitan University of Technology, Centre National de la Recherche Scientifique, Aix-Marseille Université, Bioénergétique et Ingénierie des Protéines

Language: English

Topic: Proteins in Food Systems

Subfield: Food Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W7214243871

FWCI:

Cites: 83

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Related to: 10