Work

β-adrenergic modulation of oddball responses in humans

Year: 2007

Type: article

Abstract: Detection of salient or motivationally significant stimuli is of adaptive importance. The neurophysiological correlates of this detection have been extensively studied in 'oddball' paradigms. Much theoretical data supports the role of noradrenergic systems in generating oddball responses. We combine psychopharmacology and functional neuroimaging to demonstrate modulation of neuronal responses to oddball nouns by the beta-adrenergic antagonist propranolol. Critically, responses in regions implicated in oddball detection, namely right ventrolateral prefrontal cortex and temporoparietal junction (TPJ), were abolished by propranolol. Thus, oddball responses depend on modulatory adrenergic inputs, mediated via beta-adrenergic receptors.

Source: Behavioral and Brain Functions

DOI: 10.1186/1744-9081-3-29

Authors: Bryan A Strange, Raymond J Dolan

Institutions: Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, National Hospital for Neurology and Neurosurgery

Language: English

Topic: Neural and Behavioral Psychology Studies

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,190