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[ 11 C]( R )-PK11195 PET imaging of microglial activation in multiple system atrophy

Year: 2003
Type: article
Study design: Observational Study
Abstract: Microglia, the brain's intrinsic macrophages, bind (R)-PK11195 when activated by neuronal injury. The authors used [11C](R)-PK11195 PET to localize in vivo microglial activation in patients with multiple system atrophy (MSA). Increased [11C](R)-PK11195 binding was primarily found in the dorsolateral prefrontal cortex, putamen, pallidum, pons, and substantia nigra, reflecting the known distribution of neuropathologic changes in MSA. Providing an indicator of disease activity, [11C](R)-PK11195 PET can thus be used to characterize the in vivo neuropathology of MSA.
Source: Neurology
DOI: 10.1212/01.wnl.0000078192.95645.e6
Authors: A. Gerhard, R. B. Banati, G. B. Goerres, A. Cagnin, R. Myers, R. N. Gunn, F. Turkheimer, C. D. Good, C. J. Mathias, N. Quinn, J. Schwarz, D. J. Brooks
Institutions: Montreal Neurological Institute and Hospital, University of Padua, University of Zurich, Hammersmith Hospital, National Hospital for Neurology and Neurosurgery, UCL Queen Square Institute of Neurology, Imperial College London, Leipzig University
Language: English
Subfield: Neurology
Open Access status: green
OpenAlex ID: W2075225622
FWCI: 6.888
Cites: 12
Cited by: 246
Related to: 10