Chemical Synthesis of Thrombostasin: An Anticoagulant Protein Produced by the Horn Fly Haematobia irritans
Year: 2026
Type: preprint
Abstract: Thrombostasin is a cysteine-free anticoagulant protein produced by the horn fly Haematobia irritans , featuring an unusual stretch of seven consecutive aspartate residues within the polypeptide sequence. Here, we report the first chemical synthesis of native thrombostasin and a hepta-glutamate analogue, together with assessment of their thrombin inhibitory and anticoagulant activity.
Institutions: The University of Sydney, Universidad de Cantabria, Consejo Superior de Investigaciones Científicas, Instituto de Biomedicina y Biotecnología de Cantabria, Universidade do Porto, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Instituto de Biologia Molecular e Celular
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7214275681