Work

“MIDA masking” of boronic acid therapeutics for enhanced stability and economy

Year: 2026

Type: article

Abstract: , diols and α-hydroxy acid protecting groups), imparting significant resistance to oxidation and photodegradation while minimally impacting the biological activity of the molecules in cellular assays. We propose that incorporating MIDA boronates into the synthetic routes of boronic acid-containing drugs could eliminate costly deprotection and reformulation steps in pharmaceutical development, enabling a more direct route to shelf-stable "MIDA-masked" boronic acid medicines.

Source: RSC Chemical Biology

DOI: 10.1039/d6cb00308g

Authors: Forrest G. FitzGerald, Jasmin M. Frei, Erika Zhang, Oscar J. Molina, JoLynn B. Giancola, Malo Le Chevalier, Volga Kojasoy, Ronald T. Raines

Institutions: Massachusetts Institute of Technology, Koch Institute for Integrative Cancer Research At MIT

Language: English

Topic: Organoboron and organosilicon chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,962

Funders: National Science Foundation, Eidgenössische Technische Hochschule Zürich, National Institutes of Health, National Institute of General Medical Sciences, Office of Advanced Cyberinfrastructure

Awards: G2114340465, XSEDE 2.0: Integrating, Enabling and Enhancing National Cyberinfrastructure with Expanding Community Involvement, G4875486994, Protein Chemistry, G966185934

OpenAlex ID: W7214345419

FWCI:

Cites: 63

Cited by:

Related to: 10