Consideration of the possibility of using the enzyme preparation Longidaza in the complex treatment of arthrosis of the temporomandibular joint (literature review)
Year: 2026
Type: article
Abstract: This article presents a comprehensive review of research findings analyzing the efficacy of the enzyme preparation Longidaza for the prevention and treatment of fibrous adhesions in various locations. The problem of pathological fibrogenesis, leading to chronic pain, dysfunction, and decreased quality of life, remains pressing. Standard conservative treatments often have only a symptom-modifying effect, necessitating the search for new pathogenetic approaches. This article presents information on the pharmacological properties of Longidaza and summarizes data on its clinical use in conditions associated with fibrosis (in dermatology, gynecology, pulmonology, and rheumatology). Conclusion. Due to the limited use of Longidaza in maxillofacial surgery and dentistry, based on a review of its proven effects in the treatment of fibrotic processes in various locations, it is recommended to consider its inclusion in comprehensive treatment regimens for TMJ arthrosis and the prevention of postoperative complications. To optimize and reduce rehabilitation time, it is advisable to develop protocols for the local application of Longidaza (ultraphoresis, injections) in appropriate patients based on an assessment of their clinical status.
Source: Clinical Dentistry (Russia)
Institutions: Sechenov University, Peoples' Friendship University of Russia
Language: Russian
Subfield: Oral Surgery
Field: Dentistry
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7214367976