Work

VIDA: A programmable gasdermin-mediated strategy to broaden mRNA therapeutics

Year: 2026

Type: article

Abstract: Pyroptosis, a gasdermin (GSDM)-driven form of inflammatory programmed cell death, has long been recognized for its dual function: direct elimination of infected or transformed cells and activation of the immune system via released cellular contents and pro-inflammatory mediators.1 This positions pyroptosis as a highly attractive therapeutic modality2; however, translating this mechanism into safe, precisely targeted interventions has remained challenging, particularly for viral infections.

Source: Molecular Therapy Oncology

DOI: 10.1016/j.omton.2026.201344

Authors: Yi-Jiao Huang, Cheng-Feng Qin

Institution: Academy of Military Medical Sciences

Language: English

Topic: Inflammasome and immune disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900