Apoptosis Modulation by LL-37: From Mitochondrial Cell Death to Prosurvival Signaling
Year: 2026
Type: review
Abstract: This review summarizes current knowledge on the role of human cathelicidin LL-37 in the regulation of apoptosis. LL-37 can modulate programmed cell death pathways, exerting either proapoptotic or antiapoptotic effects depending on various factors, such as cell type and peptide concentration. Data on LL-37 derivatives and their involvement in apoptosis are also discussed. Understanding the molecular mechanisms underlying LL-37 regulation of apoptosis is necessary to expand the therapeutic potential of this peptide in various pathological conditions, including cancer.
DOI: 10.3390/ijms27188351
Institution: Koltzov Institute of Developmental Biology
Language: English
Subfield: Microbiology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,499
OpenAlex ID: W7214458206