Work

OVO-like Proteins in Cancer, Immunity, and Inflammation

Year: 2026

Type: review

Abstract: as regulators of germline development, these proteins have since been found to be key determinants of epithelial lineage and differentiation in mammals. Increasing evidence implicates OVOL proteins in human disease, particularly cancer, where they participate in diverse processes including metastasis, metabolic regulation, immunity, and inflammation modulation. In this review, current advances in OVOL-related research are summarized. First, the roles of OVOL proteins in regulating epithelial-mesenchymal transition (EMT), cancer metastasis, and cellular plasticity are addressed. The discussion then extends to emerging evidence for their involvement in metabolic reprogramming, immunity, and inflammation. Finally, open questions and future research directions are discussed.

Source: Cells

DOI: 10.3390/cells15191755

Authors: Shuxian Huang, Genjian Hu, Hao Lan, Jinfeng Gan

Institution: Guilin Medical University

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,258