Work

Accumulating safety data for remote ischemic conditioning in acute pediatric neurological conditions

Year: 2026

Type: article

Abstract: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is the most common infection-triggered encephalopathy in East Asian children and one for which existing neuroprotective strategies are limited. Despite the use of therapeutic hypothermia (TH) or targeted temperature management, lasting neurological deficits in children with AESD are common. 1 , 2 In this context, Kawano and colleagues present the first prospective evaluation of remote ischemic postconditioning (RIPoC) (also termed remote ischemic conditioning (RIC)) as an adjunct to TH in children with AESD, demonstrating that the approach is safe and feasible in a pediatric brain disorder not primarily driven by ischemia-reperfusion injury. 3

Source: Pediatric Research

DOI: 10.1038/s41390-026-05402-9

Authors: Brian T. Kalish, Nicola J. Robertson

Institutions: Boston Children's Hospital, Harvard University, National Institute for Health and Care Research, UCL Biomedical Research Centre, University College London

Language: English

Topic: Infectious Encephalopathies and Encephalitis

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,390