Visualising large audiological data beyond the audiogram for auditory phenotyping
Year: 2026
Type: preprint
Abstract: The pure-tone audiogram remains the cornerstone of hearing assessment, yet it captures only part of the functional consequences of cochlear damage. Most phenotyping schemes rely solely on the audiogram, which cannot detect hidden suprathreshold dysfunction when thresholds are normal. How best to represent audiological data — as discrete phenotypes or as a continuous space — remains unresolved. Using a retrospective database from the Copenhagen Hearing and Balance Centre, Rigshospitalet (Denmark; 1995–2022; 251,986 ear-session units from 81,883 adults with normal or sensorineural audiograms), we compared linear (PCA) and non-linear (UMAP) embeddings of the audiogram alone and with word recognition in quiet (WRS max -Q). Here we show that a linear embedding suffices for the audiogram, but a non-linear one becomes advantageous once suprathreshold measures are added. PCA compressed the audiogram onto two interpretable axes, overall level and slope, explaining 91.5% of the variance, with ears forming a continuous cloud that published reference schemes tiled into overlapping regions. For the audiogram alone, UMAP recovered the same organisation. WRS max -Q varied widely among ears with similar audiograms; adding it left the PCA unchanged but reorganised the UMAP. A synthetic experiment illustrated this: ears with identical audiograms but different WRS max -Q separated under UMAP, not PCA. Combining thresholds with WRS max -Q, UMAP yielded a continuous representation — a prototype Hearing Loss Map — where each ear’s position reflects threshold and suprathreshold measures. Representing hearing loss as a location in a continuous space rather than as discrete categories may better reflect its graded nature, with clinical relevance for individual patients.
Source: medRxiv
Language: English
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7214588909