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Successful Concurrent Chemoradiotherapy for Limited-Stage Small Cell Lung Cancer in a Patient with Combined Pulmonary Fibrosis and Emphysema: A Case Report

Year: 2026

Type: article

Abstract: Interstitial lung disease (ILD) is a major risk factor for severe radiation pneumonitis (RP) during thoracic radiotherapy. We herein report a case of limited-stage small cell lung cancer with coexisting pulmonary fibrosis and emphysema treated with concurrent chemoradiotherapy. The patient exhibited fibrotic lesions consistent with a usual interstitial pneumonia pattern and a mild 18F-fluorodeoxyglucose uptake, indicating an elevated risk of RP. However, high-grade RP did not develop, likely because radiation exposure to nontarget lungs was limited. The irradiation field was spatially separated from the fibrotic regions. This case suggests that carefully selected patients with ILD may tolerate concurrent chemoradiotherapy.

Source: Internal Medicine

DOI: 10.2169/internalmedicine.7961-26

Authors: Yuki Yamamoto, Shinichi Okuzumi, Naoya Murakami, Masahiko Okada, Aya Takizawa, Sayuri Iwasawa, Hisashi Yanaihara, Yusuke Suzuki

Institutions: Kitasato University Hospital, Kitasato Institute Hospital, Kitasato University, Juntendo University

Language: English

Topic: Lung Cancer Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7214626476

FWCI:

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