Work

Stealthy lentiviral vectors: Breaking the barriers to systemic in vivo gene delivery

Year: 2026

Type: review

Abstract: delivery and the many approaches explored to circumvent immune barriers, from direct engineering of the LVV itself to pharmacological intervention. We report that while many approaches demonstrate improved efficacy, they often tackle only one aspect in isolation in a selected animal model. Therefore, we recommend researchers adopt a more holistic approach, testing a cocktail of strategies in a model that best recapitulates gene delivery to patients.

Source: Molecular Therapy Advances

DOI: 10.1016/j.omta.2026.201856

Authors: Amy L. Keating, Robert C. Carlisle, Kyriacos A. Mitrophanous, Leonard W. Seymour, Kerry D. Fisher

Institutions: University of Oxford, Oxford BioMedica (United Kingdom)

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid