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Standardising Epigenetic Data Analysis: A Prerequisite for Regulatory Uptake in Environmental Risk Assessment

Year: 2026

Type: article

Abstract: Recent advances in sequencing technologies have enabled the rapid generation of epigenomic datasets across ecotoxicologically relevant species. DNA methylation, histone modifications, and non-coding RNAs are increasingly investigated as potential biomarkers for environmental monitoring and next-generation environmental risk assessment (NGERA). However, the limited availability of standardized bioinformatic workflows currently represents one of the largest barriers to reproducibility, comparability, and regulatory acceptance of epigenetic evidence.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.23033669

Authors: Asselman, Jana, Blazquez, Mercedes, Marshall, Hollie, Mennigen, Jan, Navarro Cuenca, Anna, Navarro Martín, Laia, Ribeiro Pinto, Albano, Santos, Eduarda, Escobar-Sierra, Camilo, Pereira, Joana

Institutions: Ghent University, Consejo Superior de Investigaciones Científicas, Institut de Ciències del Mar, University of Leicester, University of Ottawa, ZeClinics (Spain), Institute of Environmental Assessment and Water Research, University of Aveiro, University of Exeter, RWTH Aachen University

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: European Commission

Award: BOOSting excellence in environmental EPIgenetics

OpenAlex ID: W7214733690

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