Work

Sleep components, depressive subdomains and quality of life in Parkinson's disease: A cross-sectional exploratory analysis

Year: 2026

Type: article

Abstract: Objective: Sleep disturbances and depressive symptoms are prevalent non-motor burdens in Parkinson's disease (PD) and are closely associated with poorer health-related quality of life (QoL). Non-motor symptoms of PD exhibit substantial heterogeneity. It remains unclear whether distinct sleep disturbances show differential correlations with physical and mental QoL, and whether specific depressive subdimensions are implicated in these relationships. This exploratory study analyzed direct and indirect associations among sleep components, depressive subdimensions, and physical-mental QoL in hospitalized patients with PD. Methods: This retrospective study analyzed data from 55 hospitalized patients with idiopathic PD who completed the Pittsburgh Sleep Quality Index (PSQI), the 24-item Hamilton Depression Rating Scale (HAMD), the Montreal Cognitive Assessment (MoCA), and the 36-Item Short Form Health Survey (SF-36). Spearman correlation and multivariable regression analyses were performed to assess bivariate associations and independent correlates of QoL. Exploratory PROCESS analyses were further implemented as hypothesis-generating secondary analyses to examine symptom-level indirect associations; all findings were interpreted as cross-sectional and non-causal. Results: = 0.617, respectively). Exploratory PROCESS analyses identified two distinct symptom-level indirect association patterns: nocturnal sleep disturbances correlated with reduced physical QoL through HAMD Retardation, and poor subjective sleep quality correlated with lower mental QoL through HAMD Anxiety/Somatization. Conclusion: Within this hospitalized PD cohort, depressive symptoms represented the dominant correlate of QoL. Specific sleep components exhibited indirect association patterns with QoL through distinct depressive subdimensions. These preliminary findings underline the heterogeneity of PD non-motor symptoms and provide a hypothesis-generating framework for future longitudinal validation and targeted intervention studies.

Source: Clinical Parkinsonism & Related Disorders

DOI: 10.1016/j.prdoa.2026.100506

Authors: Liyin Zhang, Yongxiao Shuai

Institutions: Chengdu Fifth People's Hospital, Chengdu University of Traditional Chinese Medicine

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,730