Work

Research progress on the mechanisms by which gut microbiota dysbiosis remodels the bone marrow neuroimmune microenvironment to drive age-related osteoporosis

Year: 2026

Type: article

Abstract: Age-related osteoporosis arises from the interplay between impaired bone remodeling, immune remodeling, and chronic low-grade inflammation during aging. Beyond local degeneration in bone tissue, alterations in the gut microbiota, mucosal barrier, and autonomic nervous regulation may reshape the bone marrow immune environment and amplify osteoclastogenic responses. This review integrates evidence linking the gut, neural regulation, and the bone marrow immune microenvironment. It summarizes their potential contributions to age-related bone loss and provides a conceptual framework for understanding disease mechanisms, improving risk stratification, and optimizing intervention strategies.

Source: Frontiers in Immunology

DOI: 10.3389/fimmu.2026.1884778

Authors: Haoze Zhang, Zhong Wang, Tianwen Miao, Xingwen Xie, Ning Li

Institution: Gansu University of Traditional Chinese Medicine

Language: English

Topic: Bone Metabolism and Diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801