Epoxytigliane modulation of dermal fibroblast-myofibroblast wound healing responses mediate enhanced anti-scarring properties via classical protein kinase C activation (Supplementary Data)
Year: 2026
Type: dataset
Abstract: Epoxytiglianes are a novel class of diterpene esters isolated from a native Australian rainforest plant, Fontainea picrosperma (Euphorbiaceae). Prototype epoxytigliane, EBC-46 (tigilanol tiglate), possesses potent anti-cancer properties and is currently in clinical development as a human and veterinary tumor treatment, in part mediated via the activation of classical protein kinase C (PKC) isoforms. EBC-46 also stimulates exceptional dermal wound healing in vivo upon tumor destruction, manifested as accelerated wound closure and minimal scar formation. However, the mechanisms underlying these anti-scarring responses are poorly understood. The data presented provides supplementary information to our manuscript, demonstrating the limited effects of EBC-46 and analogue, EBC-211, have on the migratory responses of human dermal fibroblasts. Specifically, the data shows the effects of EBC-46 and EBC-211 on in vitro scratch wound repopulation (automated Time-Lapse Confocal Microscopy movies over 48 h periods).
Source: Mendeley Data
DOI: 10.17632/m5f5nbwnw2
Author: Moseley, Ryan
Language: English
Topic: Wound Healing and Treatments
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7214779936